Schizophrenia spectrum disorders (SSD) represent a cluster of severe mental illnesses. Vitamins are known to play a role in various aspects of health and disease; however, the exact role of vitamins B12, B6 and folic acid in the development and progression of SSD are not clear. These vitamins play a role in the one-carbon metabolism cycle which is hypothesized to be involved in schizophrenia pathogenesis.

Introduction

Schizophrenia spectrum disorders (SSD) represent a cluster of severe mental illnesses. Diet has been identified as a modifiable risk factor and opportunity for intervention in many physical illnesses and more recently in mental illnesses such as unipolar depression; however, no dietary guidelines exist for patients with SSD.

Introduction:

Major depressive disorder (MDD) is a common chronic mental health condition and not all patients respond to pharmacotherapy. Increasing evidence suggests that dietary choices play a role in the pathogenesis of mental illness and serve as modifiable factors with utility in the treatment of these disorders. Although many mechanisms are being explored, one area of study is the role of food hypersensitivity reactions in mental health conditions.

Background:

Schizophrenia spectrum disorders impact functioning, reduce quality of life and increase the risk of physical illness and premature mortality. Nutritional intervention studies aimed at decreasing body weight have demonstrated efficacy in improving metabolic outcomes; however, few studies have explored the impact of interventions designed to modify diet on mental health outcomes.